Protein O-Fucosyltransferase 2 Adds O-Fucose to Thrombospondin Type 1 Repeats
نویسندگان
چکیده
منابع مشابه
6-alkynyl fucose is a bioorthogonal analog for O-fucosylation of epidermal growth factor-like repeats and thrombospondin type-1 repeats by protein O-fucosyltransferases 1 and 2.
Protein O-fucosyltransferase 1 (Pofut1) and protein O-fucosyltransferase 2 (Pofut2) add O-linked fucose at distinct consensus sequences in properly folded epidermal growth factor (EGF)-like repeats and thrombospondin type-1 (TSR) repeats, respectively. Glycan chain elongation past O-fucose can occur to yield a tetrasaccharide on EGF repeats and a disaccharide on TSRs. Elimination of Pofut1 in m...
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Daniel Hess, Jeremy J. Keusch, Saskia A. Lesnik Oberstein, Raoul C. M. Hennekam , and Jan Hofsteenge From the Friedrich Miescher Institute for Biomedical Research, Basel CH-4058, Switzerland, the Center for Human and Clinical Genetics, Department of Clinical Genetics, K5-R, Leiden University Medical Center, 2300 RC Leiden, The Netherlands, the Clinical and Molecular Genetics Unit, Institute of ...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2006
ISSN: 0021-9258
DOI: 10.1074/jbc.m511975200